An increased rate of falling leads to a rise in fracture risk in postmenopausal women with self-reported osteoarthritis: a prospective multinational cohort study (GLOW)
Identifieur interne : 004907 ( Main/Exploration ); précédent : 004906; suivant : 004908An increased rate of falling leads to a rise in fracture risk in postmenopausal women with self-reported osteoarthritis: a prospective multinational cohort study (GLOW)
Auteurs : Daniel Prieto-Alhambra [Espagne, Royaume-Uni] ; Xavier Nogues [Espagne] ; M Kassim Javaid [Royaume-Uni] ; Allison Wyman [États-Unis] ; Nigel K. Arden [Royaume-Uni] ; Rafael Azagra [Espagne] ; Cyrus Cooper [Royaume-Uni] ; Jonathan D. Adachi [Canada] ; Steven Boonen [Belgique] ; Roland D. Chapurlat [France] ; Juliet E. Compston [Royaume-Uni] ; Stephen H. Gehlbach [États-Unis] ; Susan L. Greenspan [États-Unis] ; Frederick H. Hooven [États-Unis] ; J Coen Netelenbos [Pays-Bas] ; Johannes Pfeilschifter [Allemagne] ; Maurizio Rossini [Italie] ; Philip N. Sambrook [Australie] ; Stuart Silverman [États-Unis] ; Ethel S. Siris [États-Unis] ; Nelson B. Watts [États-Unis] ; Adolfo Díez-Pérez [Espagne]Source :
- Annals of the Rheumatic Diseases [ 0003-4967 ] ; 2013-06.
English descriptors
- KwdEn :
- Amgen, Antiosteoporosis medication, Arthritis, Baseline, Baseline characteristics, Baseline osteoarthritis status, Better bone health, Board member, Body mass index, Bone density, Bone loss, Bone mineral density, Causal pathway, Chilcott, Clinical spine, Cohort, Consultancy work, Cumulative fracture incidence, Effect size, Epidemiological, Epidemiological research, Fracture, Fracture history, Fracture prevalence, Fracture risk, Gamble, Incident fracture, Incident fractures, Knee osteoarthritis, Merck, Multivariable, Novartis, Older adults, Osteoarthritis, Osteoporosis, Osteoporotic fractures, Outcomes research, Participant, Past year, Physician diagnosis, Postmenopausal, Postmenopausal women, Potential confounders, Primary care, Procter, Procter gamble, Pulmonary disease, Radiographic osteoarthritis, Research grants, Rheum, Roche, Secondary osteoporosis, Servier, Warner, Warner chilcott.
- Teeft :
- Amgen, Antiosteoporosis medication, Arthritis, Baseline, Baseline characteristics, Baseline osteoarthritis status, Better bone health, Board member, Body mass index, Bone density, Bone loss, Bone mineral density, Causal pathway, Chilcott, Clinical spine, Cohort, Consultancy work, Cumulative fracture incidence, Effect size, Epidemiological, Epidemiological research, Fracture, Fracture history, Fracture prevalence, Fracture risk, Gamble, Incident fracture, Incident fractures, Knee osteoarthritis, Merck, Multivariable, Novartis, Older adults, Osteoarthritis, Osteoporosis, Osteoporotic fractures, Outcomes research, Participant, Past year, Physician diagnosis, Postmenopausal, Postmenopausal women, Potential confounders, Primary care, Procter, Procter gamble, Pulmonary disease, Radiographic osteoarthritis, Research grants, Rheum, Roche, Secondary osteoporosis, Servier, Warner, Warner chilcott.
Abstract
Objectives Patients with osteoarthritis have increased bone mass but no decrease in fractures. The association between self-reported osteoarthritis and incident falls and fractures was studied in postmenopausal women. Methods The Global Longitudinal Study of Osteoporosis in Women is a prospective multinational cohort of 60 393 non-institutionalised women aged ≥55 years who had visited primary care practices within the previous 2 years. Questionnaires were mailed at yearly intervals. Patients were classified as having osteoarthritis if they answered yes to the question, ‘Has a doctor or other health provider ever said that you had osteoarthritis or degenerative joint disease?’, and this was validated against primary care records in a subsample. Information on incident falls, fractures and covariates was self-reported. Cox and Poisson models were used for incident fractures and number of falls, respectively, to compute hazard ratios (HRs) and rate ratios (RRs) for baseline osteoarthritis status. Results Of 51 386 women followed for a median of 2.9 years (interquartile range 2.1–3.0), 20 409 (40%) reported osteoarthritis. The adjusted HR for osteoarthritis predicting fracture was 1.21 (95% CI 1.13 to 1.30; p<0.0001) and the adjusted RR for falls was 1.24 (95% CI 1.22 to 1.26; p<0.0001). However, the association between osteoarthritis and fracture was not significant after adjustment for incident falls (HR 1.06 (95% CI 0.98 to 1.15; p=0.13)). Conclusions Postmenopausal women with self-reported osteoarthritis have a 20% increased risk of fracture and experience 25% more falls than those without osteoarthritis. These data suggest that increased falls are the causal pathway of the association between osteoarthritis and fractures.
Url:
- https://api.istex.fr/document/A76F8CD64DB8FA2AB9A40815A8A567204E2F0271/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886333
DOI: 10.1136/annrheumdis-2012-201451
Affiliations:
- Allemagne, Australie, Belgique, Canada, Espagne, France, Italie, Pays-Bas, Royaume-Uni, États-Unis
- Angleterre, Auvergne-Rhône-Alpes, Californie, Catalogne, Hollande-Septentrionale, Massachusetts, Ohio, Ontario, Oxfordshire, Pennsylvanie, Rhône-Alpes, État de New York
- Amsterdam, Barcelone, Hamilton (Ontario), Lyon, New York, Oxford, Pittsburgh
- Université Columbia, Université McMaster, Université d'Oxford, Université de Pittsburgh
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Le document en format XML
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Adachi</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>St Joseph's Hospital, McMaster University, Hamilton, Ontario</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Boonen, Steven" sort="Boonen, Steven" uniqKey="Boonen S" first="Steven" last="Boonen">Steven Boonen</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Division of Geriatric Medicine, Leuven University Centre for Metabolic Bone Diseases, Katholieke Universiteit Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Chapurlat, Roland D" sort="Chapurlat, Roland D" uniqKey="Chapurlat R" first="Roland D" last="Chapurlat">Roland D. Chapurlat</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Division of Rheumatology, INSERM UMR 1033, Université de Lyon, Hospices Civils de Lyon, Hôpital E Herriot, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Compston, Juliet E" sort="Compston, Juliet E" uniqKey="Compston J" first="Juliet E" last="Compston">Juliet E. Compston</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Addenbrooke's Hospital, University of Cambridge School of Clinical Medicine, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Gehlbach, Stephen H" sort="Gehlbach, Stephen H" uniqKey="Gehlbach S" first="Stephen H" last="Gehlbach">Stephen H. Gehlbach</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Outcomes Research, University of Massachusetts Medical School, Worcester, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Greenspan, Susan L" sort="Greenspan, Susan L" uniqKey="Greenspan S" first="Susan L" last="Greenspan">Susan L. Greenspan</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Geriatric Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Hooven, Frederick H" sort="Hooven, Frederick H" uniqKey="Hooven F" first="Frederick H" last="Hooven">Frederick H. Hooven</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Outcomes Research, University of Massachusetts Medical School, Worcester, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Netelenbos, J Coen" sort="Netelenbos, J Coen" uniqKey="Netelenbos J" first="J Coen" last="Netelenbos">J Coen Netelenbos</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Endocrinology, VU University Medical Centre, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Pfeilschifter, Johannes" sort="Pfeilschifter, Johannes" uniqKey="Pfeilschifter J" first="Johannes" last="Pfeilschifter">Johannes Pfeilschifter</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine III, Alfried Krupp Krankenhaus, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Rossini, Maurizio" sort="Rossini, Maurizio" uniqKey="Rossini M" first="Maurizio" last="Rossini">Maurizio Rossini</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Section of Rheumatology, Department of Medicine, University of Verona, Verona</wicri:regionArea><wicri:noRegion>Verona</wicri:noRegion></affiliation></author><author><name sortKey="Sambrook, Philip N" sort="Sambrook, Philip N" uniqKey="Sambrook P" first="Philip N" last="Sambrook">Philip N. Sambrook</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Rheumatology, University of Sydney-Royal North Shore Hospital, St Leonards, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Silverman, Stuart" sort="Silverman, Stuart" uniqKey="Silverman S" first="Stuart" last="Silverman">Stuart Silverman</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Siris, Ethel S" sort="Siris, Ethel S" uniqKey="Siris E" first="Ethel S" last="Siris">Ethel S. Siris</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Medical Center, Columbia University, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Watts, Nelson B" sort="Watts, Nelson B" uniqKey="Watts N" first="Nelson B" last="Watts">Nelson B. Watts</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mercy Health Osteoporosis and Bone Health Services, 4760 E Galbraith Road, Suite 212, Cincinnati, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Diez Perez, Adolfo" sort="Diez Perez, Adolfo" uniqKey="Diez Perez A" first="Adolfo" last="Díez-Pérez">Adolfo Díez-Pérez</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of URFOA-Internal Medicine, Hospital del Mar-IMIM-Autonomous University of Barcelona, Barcelona, RETICEF, FEDER, ISCIII Madrid</wicri:regionArea><wicri:noRegion>ISCIII Madrid</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of the Rheumatic Diseases</title><title level="j" type="abbrev">Ann Rheum Dis</title><idno type="ISSN">0003-4967</idno><idno type="eISSN">1468-2060</idno><imprint><publisher>BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><date type="published" when="2013-06">2013-06</date><biblScope unit="volume">72</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="911">911</biblScope></imprint><idno type="ISSN">0003-4967</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0003-4967</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amgen</term><term>Antiosteoporosis medication</term><term>Arthritis</term><term>Baseline</term><term>Baseline characteristics</term><term>Baseline osteoarthritis status</term><term>Better bone health</term><term>Board member</term><term>Body mass index</term><term>Bone density</term><term>Bone loss</term><term>Bone mineral density</term><term>Causal pathway</term><term>Chilcott</term><term>Clinical spine</term><term>Cohort</term><term>Consultancy work</term><term>Cumulative fracture incidence</term><term>Effect size</term><term>Epidemiological</term><term>Epidemiological research</term><term>Fracture</term><term>Fracture history</term><term>Fracture prevalence</term><term>Fracture risk</term><term>Gamble</term><term>Incident fracture</term><term>Incident fractures</term><term>Knee osteoarthritis</term><term>Merck</term><term>Multivariable</term><term>Novartis</term><term>Older adults</term><term>Osteoarthritis</term><term>Osteoporosis</term><term>Osteoporotic fractures</term><term>Outcomes research</term><term>Participant</term><term>Past year</term><term>Physician diagnosis</term><term>Postmenopausal</term><term>Postmenopausal women</term><term>Potential confounders</term><term>Primary care</term><term>Procter</term><term>Procter gamble</term><term>Pulmonary disease</term><term>Radiographic osteoarthritis</term><term>Research grants</term><term>Rheum</term><term>Roche</term><term>Secondary osteoporosis</term><term>Servier</term><term>Warner</term><term>Warner chilcott</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Amgen</term><term>Antiosteoporosis medication</term><term>Arthritis</term><term>Baseline</term><term>Baseline characteristics</term><term>Baseline osteoarthritis status</term><term>Better bone health</term><term>Board member</term><term>Body mass index</term><term>Bone density</term><term>Bone loss</term><term>Bone mineral density</term><term>Causal pathway</term><term>Chilcott</term><term>Clinical spine</term><term>Cohort</term><term>Consultancy work</term><term>Cumulative fracture incidence</term><term>Effect size</term><term>Epidemiological</term><term>Epidemiological research</term><term>Fracture</term><term>Fracture history</term><term>Fracture prevalence</term><term>Fracture risk</term><term>Gamble</term><term>Incident fracture</term><term>Incident fractures</term><term>Knee osteoarthritis</term><term>Merck</term><term>Multivariable</term><term>Novartis</term><term>Older adults</term><term>Osteoarthritis</term><term>Osteoporosis</term><term>Osteoporotic fractures</term><term>Outcomes research</term><term>Participant</term><term>Past year</term><term>Physician diagnosis</term><term>Postmenopausal</term><term>Postmenopausal women</term><term>Potential confounders</term><term>Primary care</term><term>Procter</term><term>Procter gamble</term><term>Pulmonary disease</term><term>Radiographic osteoarthritis</term><term>Research grants</term><term>Rheum</term><term>Roche</term><term>Secondary osteoporosis</term><term>Servier</term><term>Warner</term><term>Warner chilcott</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Objectives Patients with osteoarthritis have increased bone mass but no decrease in fractures. The association between self-reported osteoarthritis and incident falls and fractures was studied in postmenopausal women. Methods The Global Longitudinal Study of Osteoporosis in Women is a prospective multinational cohort of 60 393 non-institutionalised women aged ≥55 years who had visited primary care practices within the previous 2 years. Questionnaires were mailed at yearly intervals. Patients were classified as having osteoarthritis if they answered yes to the question, ‘Has a doctor or other health provider ever said that you had osteoarthritis or degenerative joint disease?’, and this was validated against primary care records in a subsample. Information on incident falls, fractures and covariates was self-reported. Cox and Poisson models were used for incident fractures and number of falls, respectively, to compute hazard ratios (HRs) and rate ratios (RRs) for baseline osteoarthritis status. Results Of 51 386 women followed for a median of 2.9 years (interquartile range 2.1–3.0), 20 409 (40%) reported osteoarthritis. The adjusted HR for osteoarthritis predicting fracture was 1.21 (95% CI 1.13 to 1.30; p<0.0001) and the adjusted RR for falls was 1.24 (95% CI 1.22 to 1.26; p<0.0001). However, the association between osteoarthritis and fracture was not significant after adjustment for incident falls (HR 1.06 (95% CI 0.98 to 1.15; p=0.13)). Conclusions Postmenopausal women with self-reported osteoarthritis have a 20% increased risk of fracture and experience 25% more falls than those without osteoarthritis. These data suggest that increased falls are the causal pathway of the association between osteoarthritis and fractures.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Canada</li><li>Espagne</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Auvergne-Rhône-Alpes</li><li>Californie</li><li>Catalogne</li><li>Hollande-Septentrionale</li><li>Massachusetts</li><li>Ohio</li><li>Ontario</li><li>Oxfordshire</li><li>Pennsylvanie</li><li>Rhône-Alpes</li><li>État de New York</li></region><settlement><li>Amsterdam</li><li>Barcelone</li><li>Hamilton (Ontario)</li><li>Lyon</li><li>New York</li><li>Oxford</li><li>Pittsburgh</li></settlement><orgName><li>Université Columbia</li><li>Université McMaster</li><li>Université d'Oxford</li><li>Université de Pittsburgh</li></orgName></list><tree><country name="Espagne"><noRegion><name sortKey="Prieto Alhambra, Daniel" sort="Prieto Alhambra, Daniel" uniqKey="Prieto Alhambra D" first="Daniel" last="Prieto-Alhambra">Daniel Prieto-Alhambra</name></noRegion><name sortKey="Azagra, Rafael" sort="Azagra, Rafael" uniqKey="Azagra R" first="Rafael" last="Azagra">Rafael Azagra</name><name sortKey="Diez Perez, Adolfo" sort="Diez Perez, Adolfo" uniqKey="Diez Perez A" first="Adolfo" last="Díez-Pérez">Adolfo Díez-Pérez</name><name sortKey="Nogues, Xavier" sort="Nogues, Xavier" uniqKey="Nogues X" first="Xavier" last="Nogues">Xavier Nogues</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Prieto Alhambra, Daniel" sort="Prieto Alhambra, Daniel" uniqKey="Prieto Alhambra D" first="Daniel" last="Prieto-Alhambra">Daniel Prieto-Alhambra</name></region><name sortKey="Arden, Nigel K" sort="Arden, Nigel K" uniqKey="Arden N" first="Nigel K" last="Arden">Nigel K. Arden</name><name sortKey="Compston, Juliet E" sort="Compston, Juliet E" uniqKey="Compston J" first="Juliet E" last="Compston">Juliet E. Compston</name><name sortKey="Cooper, Cyrus" sort="Cooper, Cyrus" uniqKey="Cooper C" first="Cyrus" last="Cooper">Cyrus Cooper</name><name sortKey="Cooper, Cyrus" sort="Cooper, Cyrus" uniqKey="Cooper C" first="Cyrus" last="Cooper">Cyrus Cooper</name><name sortKey="Javaid, M Kassim" sort="Javaid, M Kassim" uniqKey="Javaid M" first="M Kassim" last="Javaid">M Kassim Javaid</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Wyman, Allison" sort="Wyman, Allison" uniqKey="Wyman A" first="Allison" last="Wyman">Allison Wyman</name></region><name sortKey="Gehlbach, Stephen H" sort="Gehlbach, Stephen H" uniqKey="Gehlbach S" first="Stephen H" last="Gehlbach">Stephen H. Gehlbach</name><name sortKey="Greenspan, Susan L" sort="Greenspan, Susan L" uniqKey="Greenspan S" first="Susan L" last="Greenspan">Susan L. Greenspan</name><name sortKey="Hooven, Frederick H" sort="Hooven, Frederick H" uniqKey="Hooven F" first="Frederick H" last="Hooven">Frederick H. Hooven</name><name sortKey="Silverman, Stuart" sort="Silverman, Stuart" uniqKey="Silverman S" first="Stuart" last="Silverman">Stuart Silverman</name><name sortKey="Siris, Ethel S" sort="Siris, Ethel S" uniqKey="Siris E" first="Ethel S" last="Siris">Ethel S. Siris</name><name sortKey="Watts, Nelson B" sort="Watts, Nelson B" uniqKey="Watts N" first="Nelson B" last="Watts">Nelson B. Watts</name></country><country name="Canada"><region name="Ontario"><name sortKey="Adachi, Jonathan D" sort="Adachi, Jonathan D" uniqKey="Adachi J" first="Jonathan D" last="Adachi">Jonathan D. Adachi</name></region></country><country name="Belgique"><noRegion><name sortKey="Boonen, Steven" sort="Boonen, Steven" uniqKey="Boonen S" first="Steven" last="Boonen">Steven Boonen</name></noRegion></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Chapurlat, Roland D" sort="Chapurlat, Roland D" uniqKey="Chapurlat R" first="Roland D" last="Chapurlat">Roland D. Chapurlat</name></region></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Netelenbos, J Coen" sort="Netelenbos, J Coen" uniqKey="Netelenbos J" first="J Coen" last="Netelenbos">J Coen Netelenbos</name></region></country><country name="Allemagne"><noRegion><name sortKey="Pfeilschifter, Johannes" sort="Pfeilschifter, Johannes" uniqKey="Pfeilschifter J" first="Johannes" last="Pfeilschifter">Johannes Pfeilschifter</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Rossini, Maurizio" sort="Rossini, Maurizio" uniqKey="Rossini M" first="Maurizio" last="Rossini">Maurizio Rossini</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Sambrook, Philip N" sort="Sambrook, Philip N" uniqKey="Sambrook P" first="Philip N" last="Sambrook">Philip N. Sambrook</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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